Aromatic Substitution of Disubstituted Benzenes

• The more active the group the more influential in directing ability

  • Strong Activators > Moderate Activators > Weak Activators > Weakly Deactivators > Moderate Deactivators > Strong Deactivators

• Examples (Problem 15.20)

  • p-NitroPhenol
  • m-Nitro-Triflouromethylbenzene
  • p-MethylAcetanilide

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CH3